diff --git a/Marlin/src/core/boards.h b/Marlin/src/core/boards.h
index 5cde344b4d..12e72517a3 100644
--- a/Marlin/src/core/boards.h
+++ b/Marlin/src/core/boards.h
@@ -54,6 +54,12 @@
 #define BOARD_RAMPS_PLUS_EEF          1033  // RAMPS Plus 3DYMY (Power outputs: Hotend0, Hotend1, Fan)
 #define BOARD_RAMPS_PLUS_SF           1034  // RAMPS Plus 3DYMY (Power outputs: Spindle, Controller Fan)
 
+#define BOARD_RAMPS_BTT_16_PLUS_EFB   1035  // RAMPS 1.6+ (Power outputs: Hotend, Fan, Bed)
+#define BOARD_RAMPS_BTT_16_PLUS_EEB   1036  // RAMPS 1.6+ (Power outputs: Hotend0, Hotend1, Bed)
+#define BOARD_RAMPS_BTT_16_PLUS_EFF   1037  // RAMPS 1.6+ (Power outputs: Hotend, Fan0, Fan1)
+#define BOARD_RAMPS_BTT_16_PLUS_EEF   1038  // RAMPS 1.6+ (Power outputs: Hotend0, Hotend1, Fan)
+#define BOARD_RAMPS_BTT_16_PLUS_SF    1039  // RAMPS 1.6+ (Power outputs: Spindle, Controller Fan)
+
 //
 // RAMPS Derivatives - ATmega1280, ATmega2560
 //
diff --git a/Marlin/src/pins/pins.h b/Marlin/src/pins/pins.h
index 9a3b3c3c22..7e235ca80a 100644
--- a/Marlin/src/pins/pins.h
+++ b/Marlin/src/pins/pins.h
@@ -38,15 +38,15 @@
 #define MAX_E_STEPPERS 8
 
 #if NONE(FET_ORDER_EEF, FET_ORDER_EEB, FET_ORDER_EFF, FET_ORDER_EFB, FET_ORDER_SF)
-  #if   MB(RAMPS_13_EFB, RAMPS_14_EFB, RAMPS_PLUS_EFB, RAMPS_14_RE_ARM_EFB, RAMPS_SMART_EFB, RAMPS_DUO_EFB, RAMPS4DUE_EFB)
+  #if   MB(RAMPS_13_EFB, RAMPS_14_EFB, RAMPS_PLUS_EFB, RAMPS_14_RE_ARM_EFB, RAMPS_SMART_EFB, RAMPS_DUO_EFB, RAMPS4DUE_EFB, RAMPS_BTT_16_PLUS_EFB)
     #define FET_ORDER_EFB 1
-  #elif MB(RAMPS_13_EEB, RAMPS_14_EEB, RAMPS_PLUS_EEB, RAMPS_14_RE_ARM_EEB, RAMPS_SMART_EEB, RAMPS_DUO_EEB, RAMPS4DUE_EEB)
+  #elif MB(RAMPS_13_EEB, RAMPS_14_EEB, RAMPS_PLUS_EEB, RAMPS_14_RE_ARM_EEB, RAMPS_SMART_EEB, RAMPS_DUO_EEB, RAMPS4DUE_EEB, RAMPS_BTT_16_PLUS_EEB)
     #define FET_ORDER_EEB 1
-  #elif MB(RAMPS_13_EFF, RAMPS_14_EFF, RAMPS_PLUS_EFF, RAMPS_14_RE_ARM_EFF, RAMPS_SMART_EFF, RAMPS_DUO_EFF, RAMPS4DUE_EFF)
+  #elif MB(RAMPS_13_EFF, RAMPS_14_EFF, RAMPS_PLUS_EFF, RAMPS_14_RE_ARM_EFF, RAMPS_SMART_EFF, RAMPS_DUO_EFF, RAMPS4DUE_EFF, RAMPS_BTT_16_PLUS_EFF)
     #define FET_ORDER_EFF 1
-  #elif MB(RAMPS_13_EEF, RAMPS_14_EEF, RAMPS_PLUS_EEF, RAMPS_14_RE_ARM_EEF, RAMPS_SMART_EEF, RAMPS_DUO_EEF, RAMPS4DUE_EEF)
+  #elif MB(RAMPS_13_EEF, RAMPS_14_EEF, RAMPS_PLUS_EEF, RAMPS_14_RE_ARM_EEF, RAMPS_SMART_EEF, RAMPS_DUO_EEF, RAMPS4DUE_EEF, RAMPS_BTT_16_PLUS_EEF)
     #define FET_ORDER_EEF 1
-  #elif MB(RAMPS_13_SF,  RAMPS_14_SF,  RAMPS_PLUS_SF,  RAMPS_14_RE_ARM_SF,  RAMPS_SMART_SF,  RAMPS_DUO_SF,  RAMPS4DUE_SF)
+  #elif MB(RAMPS_13_SF,  RAMPS_14_SF,  RAMPS_PLUS_SF,  RAMPS_14_RE_ARM_SF,  RAMPS_SMART_SF,  RAMPS_DUO_SF,  RAMPS4DUE_SF,  RAMPS_BTT_16_PLUS_SF)
     #define FET_ORDER_SF 1
   #elif HAS_MULTI_HOTEND || (HAS_EXTRUDERS && HAS_CUTTER)
     #if TEMP_SENSOR_BED
@@ -124,7 +124,7 @@
 #endif
 
 //
-// RAMPS 1.3 / 1.4 - ATmega1280, ATmega2560
+// RAMPS 1.3 / 1.4 / 1.6+ - ATmega1280, ATmega2560
 //
 
 #if MB(RAMPS_OLD)
@@ -135,6 +135,8 @@
   #include "ramps/pins_RAMPS.h"                     // ATmega2560, ATmega1280               env:mega2560 env:mega1280
 #elif MB(RAMPS_PLUS_EFB, RAMPS_PLUS_EEB, RAMPS_PLUS_EFF, RAMPS_PLUS_EEF, RAMPS_PLUS_SF)
   #include "ramps/pins_RAMPS_PLUS.h"                // ATmega2560, ATmega1280               env:mega2560 env:mega1280
+#elif MB(RAMPS_BTT_16_PLUS_EFB, RAMPS_BTT_16_PLUS_EEB, RAMPS_BTT_16_PLUS_EFF, RAMPS_BTT_16_PLUS_EEF, RAMPS_BTT_16_PLUS_SF)
+  #include "ramps/pins_RAMPS_BTT_16_PLUS.h"         // ATmega2560, ATmega1280               env:mega2560 env:mega1280
 
 //
 // RAMPS Derivatives - ATmega1280, ATmega2560
diff --git a/Marlin/src/pins/ramps/pins_RAMPS_BTT_16_PLUS.h b/Marlin/src/pins/ramps/pins_RAMPS_BTT_16_PLUS.h
new file mode 100644
index 0000000000..803a1de30b
--- /dev/null
+++ b/Marlin/src/pins/ramps/pins_RAMPS_BTT_16_PLUS.h
@@ -0,0 +1,49 @@
+/**
+ * Marlin 3D Printer Firmware
+ * Copyright (c) 2023 MarlinFirmware [https://github.com/MarlinFirmware/Marlin]
+ *
+ * Based on Sprinter and grbl.
+ * Copyright (c) 2011 Camiel Gubbels / Erik van der Zalm
+ *
+ * This program is free software: you can redistribute it and/or modify
+ * it under the terms of the GNU General Public License as published by
+ * the Free Software Foundation, either version 3 of the License, or
+ * (at your option) any later version.
+ *
+ * This program is distributed in the hope that it will be useful,
+ * but WITHOUT ANY WARRANTY; without even the implied warranty of
+ * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+ * GNU General Public License for more details.
+ *
+ * You should have received a copy of the GNU General Public License
+ * along with this program.  If not, see <https://www.gnu.org/licenses/>.
+ *
+ */
+#pragma once
+
+/**
+ * Arduino Mega with RAMPS BTT v1.6+
+ * Schematic: https://github.com/bigtreetech/ramps-1.6/blob/master/Ramps1.6/hardware/R6%2B-SCH.pdf
+ *
+ * Differences from RAMPS v1.4:
+ *  - SPI Stepper drivers use AVR hardware SPI pins
+ *  - SPI Stepper CS pins are different
+ */
+
+#include "env_validate.h"
+
+#define BOARD_INFO_NAME "RAMPS BTT 1.6+"
+
+#if HAS_TMC_SPI && DISABLED(TMC_USE_SW_SPI)
+  #define TMC_SPI_MOSI                      MOSI  // 51
+  #define TMC_SPI_MISO                      MISO  // 50
+  #define TMC_SPI_SCK                        SCK  // 52
+#endif
+
+#define X_CS_PIN                              63  // A0
+#define Y_CS_PIN                              40
+#define Z_CS_PIN                              42
+#define E0_CS_PIN                             65  // A11
+#define E1_CS_PIN                             66  // A12
+
+#include "pins_RAMPS.h"