diff --git a/MdeModulePkg/Bus/Pci/XhciDxe/XhciSched.c b/MdeModulePkg/Bus/Pci/XhciDxe/XhciSched.c
index eed342bdb8..bf9d24a579 100644
--- a/MdeModulePkg/Bus/Pci/XhciDxe/XhciSched.c
+++ b/MdeModulePkg/Bus/Pci/XhciDxe/XhciSched.c
@@ -1684,9 +1684,11 @@ XhcPollPortStatusChange (
   EFI_STATUS        Status;
   UINT8             Speed;
   UINT8             SlotId;
+  UINT8             Retries;
   USB_DEV_ROUTE     RouteChart;
 
   Status = EFI_SUCCESS;
+  Retries = XHC_INIT_DEVICE_SLOT_RETRIES;
 
   if ((PortState->PortChangeStatus & (USB_PORT_STAT_C_CONNECTION | USB_PORT_STAT_C_ENABLE | USB_PORT_STAT_C_OVERCURRENT | USB_PORT_STAT_C_RESET)) == 0) {
     return EFI_SUCCESS;
@@ -1728,17 +1730,29 @@ XhcPollPortStatusChange (
     } else if ((PortState->PortStatus & USB_PORT_STAT_SUPER_SPEED) != 0) {
       Speed = EFI_USB_SPEED_SUPER;
     }
-    //
-    // Execute Enable_Slot cmd for attached device, initialize device context and assign device address.
-    //
-    SlotId = XhcRouteStringToSlotId (Xhc, RouteChart);
-    if ((SlotId == 0) && ((PortState->PortChangeStatus & USB_PORT_STAT_C_RESET) != 0)) {
-      if (Xhc->HcCParams.Data.Csz == 0) {
-        Status = XhcInitializeDeviceSlot (Xhc, ParentRouteChart, Port, RouteChart, Speed);
-      } else {
-        Status = XhcInitializeDeviceSlot64 (Xhc, ParentRouteChart, Port, RouteChart, Speed);
+
+    do {
+      //
+      // Execute Enable_Slot cmd for attached device, initialize device context and assign device address.
+      //
+      SlotId = XhcRouteStringToSlotId (Xhc, RouteChart);
+      if ((SlotId == 0) && ((PortState->PortChangeStatus & USB_PORT_STAT_C_RESET) != 0)) {
+        if (Xhc->HcCParams.Data.Csz == 0) {
+          Status = XhcInitializeDeviceSlot (Xhc, ParentRouteChart, Port, RouteChart, Speed);
+        } else {
+          Status = XhcInitializeDeviceSlot64 (Xhc, ParentRouteChart, Port, RouteChart, Speed);
+        }
       }
-    }
+
+      //
+      // According to the xHCI specification (section 4.6.5), "a USB Transaction
+      // Error Completion Code for an Address Device Command may be due to a Stall
+      // response from a device. Software should issue a Disable Slot Command for
+      // the Device Slot then an Enable Slot Command to recover from this error."
+      // Therefore, retry the device slot initialization if it fails due to a
+      // device error.
+      //
+    } while ((Status == EFI_DEVICE_ERROR) && (Retries-- != 0));
   }
 
   return Status;
diff --git a/MdeModulePkg/Bus/Pci/XhciDxe/XhciSched.h b/MdeModulePkg/Bus/Pci/XhciDxe/XhciSched.h
index 2f18995021..3f9cdb1c36 100644
--- a/MdeModulePkg/Bus/Pci/XhciDxe/XhciSched.h
+++ b/MdeModulePkg/Bus/Pci/XhciDxe/XhciSched.h
@@ -11,6 +11,7 @@ SPDX-License-Identifier: BSD-2-Clause-Patent
 #define _EFI_XHCI_SCHED_H_
 
 #define XHC_URB_SIG      SIGNATURE_32 ('U', 'S', 'B', 'R')
+#define XHC_INIT_DEVICE_SLOT_RETRIES 1
 
 //
 // Transfer types, used in URB to identify the transfer type