diff --git a/MdePkg/Include/X64/ProcessorBind.h b/MdePkg/Include/X64/ProcessorBind.h
index 705104af06..a4aad3e524 100644
--- a/MdePkg/Include/X64/ProcessorBind.h
+++ b/MdePkg/Include/X64/ProcessorBind.h
@@ -27,6 +27,15 @@
 #pragma pack()
 #endif
 
+#if defined(__GNUC__) && defined(__pic__)
+//
+// Mark all symbol declarations and references as protected, meaning they will
+// not be subject to symbol preemption. This allows the compiler to refer to
+// symbols directly using relative references rather than via the GOT, which
+// contains absolute symbol addresses that are subject to runtime relocation.
+//
+#pragma GCC visibility push (protected)
+#endif
 
 #if defined(__INTEL_COMPILER)
 //