diff --git a/MdePkg/Library/UefiUsbLib/UsbDxeLib.c b/MdePkg/Library/UefiUsbLib/UsbDxeLib.c
index c27fb03499..521fdd0101 100644
--- a/MdePkg/Library/UefiUsbLib/UsbDxeLib.c
+++ b/MdePkg/Library/UefiUsbLib/UsbDxeLib.c
@@ -177,6 +177,8 @@ UsbGetInterface (
   ASSERT (AlternateSetting != NULL);
   ASSERT (Status != NULL);
 
+  *AlternateSetting = 0;
+
   ZeroMem (&DevReq, sizeof (EFI_USB_DEVICE_REQUEST));
 
   DevReq.RequestType  = USB_DEV_GET_INTERFACE_REQ_TYPE;
@@ -283,6 +285,8 @@ UsbGetConfiguration (
   ASSERT (ConfigurationValue != NULL);
   ASSERT (Status != NULL);
 
+  *ConfigurationValue = 0;
+
   ZeroMem (&DevReq, sizeof (EFI_USB_DEVICE_REQUEST));
 
   DevReq.RequestType  = USB_DEV_GET_CONFIGURATION_REQ_TYPE;