diff --git a/MdePkg/Include/Base.h b/MdePkg/Include/Base.h
index ce20b5f01d..ec096133ba 100644
--- a/MdePkg/Include/Base.h
+++ b/MdePkg/Include/Base.h
@@ -843,6 +843,20 @@ typedef UINTN  *BASE_LIST;
 #define OFFSET_OF(TYPE, Field) ((UINTN) &(((TYPE *)0)->Field))
 #endif
 
+/**
+  Portable definition for compile time assertions.
+  Equivalent to C11 static_assert macro from assert.h.
+
+  @param  Expression  Boolean expression.
+  @param  Message     Raised compiler diagnostic message when expression is false.
+
+**/
+#ifdef _MSC_EXTENSIONS
+  #define STATIC_ASSERT static_assert
+#else
+  #define STATIC_ASSERT _Static_assert
+#endif
+
 /**
   Macro that returns a pointer to the data structure that contains a specified field of
   that data structure.  This is a lightweight method to hide information by placing a