diff --git a/BaseTools/Source/Python/GenFds/FdfParser.py b/BaseTools/Source/Python/GenFds/FdfParser.py
index 4be790a819..8de0b48ff6 100644
--- a/BaseTools/Source/Python/GenFds/FdfParser.py
+++ b/BaseTools/Source/Python/GenFds/FdfParser.py
@@ -423,6 +423,8 @@ class FdfParser:
 
     def __StringToList(self):
         self.Profile.FileLinesList = [list(s) for s in self.Profile.FileLinesList]
+        if not self.Profile.FileLinesList:
+            EdkLogger.error('FdfParser', FILE_READ_FAILURE, 'The file is empty!', File=self.FileName)
         self.Profile.FileLinesList[-1].append(' ')
 
     def __ReplaceFragment(self, StartPos, EndPos, Value = ' '):