diff --git a/MdeModulePkg/Bus/Pci/NvmExpressDxe/NvmExpressHci.c b/MdeModulePkg/Bus/Pci/NvmExpressDxe/NvmExpressHci.c
index a173504cdf..51cff3c96c 100644
--- a/MdeModulePkg/Bus/Pci/NvmExpressDxe/NvmExpressHci.c
+++ b/MdeModulePkg/Bus/Pci/NvmExpressDxe/NvmExpressHci.c
@@ -862,6 +862,19 @@ NvmeControllerInit (
     return Status;
   }
 
+  //
+  // Enable 64-bit DMA support in the PCI layer.
+  //
+  Status = PciIo->Attributes (
+                    PciIo,
+                    EfiPciIoAttributeOperationEnable,
+                    EFI_PCI_IO_ATTRIBUTE_DUAL_ADDRESS_CYCLE,
+                    NULL
+                    );
+  if (EFI_ERROR (Status)) {
+    DEBUG ((EFI_D_WARN, "NvmeControllerInit: failed to enable 64-bit DMA (%r)\n", Status));
+  }
+
   //
   // Read the Controller Capabilities register and verify that the NVM command set is supported
   //