diff --git a/CryptoPkg/Library/OpensslLib/process_files.pl b/CryptoPkg/Library/OpensslLib/process_files.pl
index f6e1f43641..6c136cca09 100755
--- a/CryptoPkg/Library/OpensslLib/process_files.pl
+++ b/CryptoPkg/Library/OpensslLib/process_files.pl
@@ -90,7 +90,10 @@ BEGIN {
                 "no-threads",
                 "no-ts",
                 "no-ui",
-                "no-whirlpool"
+                "no-whirlpool",
+                # OpenSSL1_1_1b doesn't support default rand-seed-os for UEFI
+                # UEFI only support --with-rand-seed=none
+                "--with-rand-seed=none"
                 ) == 0 ||
                     die "OpenSSL Configure failed!\n";