diff --git a/MdeModulePkg/Core/Dxe/Hand/Locate.c b/MdeModulePkg/Core/Dxe/Hand/Locate.c
index 861cf12ee6..5a30c5264f 100644
--- a/MdeModulePkg/Core/Dxe/Hand/Locate.c
+++ b/MdeModulePkg/Core/Dxe/Hand/Locate.c
@@ -465,14 +465,6 @@ CoreLocateDevicePath (
 
   SourceSize = (UINTN) TmpDevicePath - (UINTN) SourcePath;
 
-  //
-  // The source path can only have 1 instance
-  //
-  if (IsDevicePathMultiInstance (SourcePath)) {
-    DEBUG((DEBUG_ERROR, "LocateDevicePath: Device path has too many instances\n"));
-    return EFI_INVALID_PARAMETER;
-  }
-
   //
   // Get a list of all handles that support the requested protocol
   //