diff --git a/MdeModulePkg/Bus/Usb/UsbMouseAbsolutePointerDxe/UsbMouseAbsolutePointer.c b/MdeModulePkg/Bus/Usb/UsbMouseAbsolutePointerDxe/UsbMouseAbsolutePointer.c
index 2f3cf9aae2..8c2edb4f99 100644
--- a/MdeModulePkg/Bus/Usb/UsbMouseAbsolutePointerDxe/UsbMouseAbsolutePointer.c
+++ b/MdeModulePkg/Bus/Usb/UsbMouseAbsolutePointerDxe/UsbMouseAbsolutePointer.c
@@ -599,7 +599,7 @@ InitializeUsbMouseDevice (
   if (Protocol != BOOT_PROTOCOL) {
     Status = UsbSetProtocolRequest (
                UsbIo,
-               0,
+               UsbMouseAbsolutePointerDev->InterfaceDescriptor.InterfaceNumber,
                BOOT_PROTOCOL
                );
 
diff --git a/MdeModulePkg/Bus/Usb/UsbMouseDxe/UsbMouse.c b/MdeModulePkg/Bus/Usb/UsbMouseDxe/UsbMouse.c
index f51dbfa1cf..d81eaf7eae 100644
--- a/MdeModulePkg/Bus/Usb/UsbMouseDxe/UsbMouse.c
+++ b/MdeModulePkg/Bus/Usb/UsbMouseDxe/UsbMouse.c
@@ -605,7 +605,7 @@ InitializeUsbMouseDevice (
   if (Protocol != BOOT_PROTOCOL) {
     Status = UsbSetProtocolRequest (
                UsbIo,
-               0,
+               UsbMouseDev->InterfaceDescriptor.InterfaceNumber,
                BOOT_PROTOCOL
                );