diff --git a/MdePkg/Include/Base.h b/MdePkg/Include/Base.h
index 5b311f6648..21a603a903 100644
--- a/MdePkg/Include/Base.h
+++ b/MdePkg/Include/Base.h
@@ -91,7 +91,7 @@ VERIFY_SIZE_OF (__VERIFY_UINT32_ENUM_SIZE, 4);
 //  if the /OPT:REF linker option is used. We defined a macro as this is a
 //  a non standard extension
 //
-#if defined(_MSC_EXTENSIONS) && !defined (MDE_CPU_EBC)
+#if defined(_MSC_EXTENSIONS) && _MSC_VER < 1800 && !defined (MDE_CPU_EBC)
   ///
   /// Remove global variable from the linked image if there are no references to
   /// it after all compiler and linker optimizations have been performed.