diff --git a/MdePkg/Library/BaseLib/BaseLib.msa b/MdePkg/Library/BaseLib/BaseLib.msa
index 380674a835..7719c3af01 100644
--- a/MdePkg/Library/BaseLib/BaseLib.msa
+++ b/MdePkg/Library/BaseLib/BaseLib.msa
@@ -273,6 +273,7 @@ WITHOUT WARRANTIES OR REPRESENTATIONS OF ANY KIND, EITHER EXPRESS OR IMPLIED.
       <Filename>Ipf/InterlockedCompareExchange64.s</Filename>
       <Filename>Ipf/Synchronization.c</Filename>
       <Filename>Ipf/CpuPause.s</Filename>
+      <Filename>Ipf/CpuFlushTlb.s</Filename>
     </Arch>
     <Arch ArchType="EBC">
       <Filename>Math64.c</Filename>
diff --git a/MdePkg/Library/BaseLib/Ipf/CpuFlushTlb.s b/MdePkg/Library/BaseLib/Ipf/CpuFlushTlb.s
new file mode 100644
index 0000000000..0afd87e88b
--- /dev/null
+++ b/MdePkg/Library/BaseLib/Ipf/CpuFlushTlb.s
@@ -0,0 +1,29 @@
+/// @file
+///   CpuFlushTlb() function for Itanium-based architecture.
+///
+/// Copyright (c) 2006, Intel Corporation
+/// All rights reserved. This program and the accompanying materials
+/// are licensed and made available under the terms and conditions of the BSD License
+/// which accompanies this distribution.  The full text of the license may be found at
+/// http://opensource.org/licenses/bsd-license.php
+///
+/// THE PROGRAM IS DISTRIBUTED UNDER THE BSD LICENSE ON AN "AS IS" BASIS,
+/// WITHOUT WARRANTIES OR REPRESENTATIONS OF ANY KIND, EITHER EXPRESS OR IMPLIED.
+///
+/// Module Name:  CpuFlushTlb.s
+///
+///
+
+.auto
+.text
+
+.proc   CpuFlushTlb
+.type   CpuFlushTlb, @function
+CpuFlushTlb::
+        mov                 r8  = ip
+        mov                 r9  = -1
+        dep.z               r10 = -1, 61, 3
+        and                 r8  = r8, r10
+        ptc.l               r8, r9
+        br.ret.sptk.many    b0
+.endp