diff --git a/MdePkg/Include/Ia32/Nasm.inc b/MdePkg/Include/Ia32/Nasm.inc
index c794d9ece3..e92c032bd8 100644
--- a/MdePkg/Include/Ia32/Nasm.inc
+++ b/MdePkg/Include/Ia32/Nasm.inc
@@ -1,6 +1,6 @@
 ;------------------------------------------------------------------------------
 ;
-; Copyright (c) 2019 - 2021, Intel Corporation. All rights reserved.<BR>
+; Copyright (c) 2019 - 2022, Intel Corporation. All rights reserved.<BR>
 ; SPDX-License-Identifier: BSD-2-Clause-Patent
 ;
 ; Abstract:
@@ -9,30 +9,6 @@
 ;
 ;------------------------------------------------------------------------------
 
-%macro SAVEPREVSSP     0
-    DB 0xF3, 0x0F, 0x01, 0xEA
-%endmacro
-
-%macro CLRSSBSY_EAX    0
-    DB 0x67, 0xF3, 0x0F, 0xAE, 0x30
-%endmacro
-
-%macro RSTORSSP_EAX    0
-    DB 0x67, 0xF3, 0x0F, 0x01, 0x28
-%endmacro
-
-%macro SETSSBSY        0
-    DB 0xF3, 0x0F, 0x01, 0xE8
-%endmacro
-
-%macro READSSP_EAX     0
-    DB 0xF3, 0x0F, 0x1E, 0xC8
-%endmacro
-
-%macro INCSSP_EAX      0
-    DB 0xF3, 0x0F, 0xAE, 0xE8
-%endmacro
-
 ; NASM provides built-in macros STRUC and ENDSTRUC for structure definition.
 ; For example, to define a structure called mytype containing a longword,
 ; a word, a byte and a string of bytes, you might code
diff --git a/MdePkg/Include/X64/Nasm.inc b/MdePkg/Include/X64/Nasm.inc
index cfb14edc94..bb77ca6c32 100644
--- a/MdePkg/Include/X64/Nasm.inc
+++ b/MdePkg/Include/X64/Nasm.inc
@@ -1,6 +1,6 @@
 ;------------------------------------------------------------------------------
 ;
-; Copyright (c) 2019 - 2021, Intel Corporation. All rights reserved.<BR>
+; Copyright (c) 2019 - 2022, Intel Corporation. All rights reserved.<BR>
 ; SPDX-License-Identifier: BSD-2-Clause-Patent
 ;
 ; Abstract:
@@ -9,30 +9,6 @@
 ;
 ;------------------------------------------------------------------------------
 
-%macro SAVEPREVSSP     0
-    DB 0xF3, 0x0F, 0x01, 0xEA
-%endmacro
-
-%macro CLRSSBSY_RAX    0
-    DB 0xF3, 0x0F, 0xAE, 0x30
-%endmacro
-
-%macro RSTORSSP_RAX    0
-    DB 0xF3, 0x0F, 0x01, 0x28
-%endmacro
-
-%macro SETSSBSY        0
-    DB 0xF3, 0x0F, 0x01, 0xE8
-%endmacro
-
-%macro READSSP_RAX     0
-    DB 0xF3, 0x48, 0x0F, 0x1E, 0xC8
-%endmacro
-
-%macro INCSSP_RAX      0
-    DB 0xF3, 0x48, 0x0F, 0xAE, 0xE8
-%endmacro
-
 ;
 ; Macro for the PVALIDATE instruction, defined in AMD APM volume 3.
 ; NASM feature request URL: https://bugzilla.nasm.us/show_bug.cgi?id=3392753