diff --git a/CryptoPkg/Library/Include/CrtLibSupport.h b/CryptoPkg/Library/Include/CrtLibSupport.h
index 7a82f1d406..b1dff03bdc 100644
--- a/CryptoPkg/Library/Include/CrtLibSupport.h
+++ b/CryptoPkg/Library/Include/CrtLibSupport.h
@@ -2,7 +2,7 @@
   Root include file of C runtime library to support building the third-party
   cryptographic library.
 
-Copyright (c) 2010 - 2019, Intel Corporation. All rights reserved.<BR>
+Copyright (c) 2010 - 2021, Intel Corporation. All rights reserved.<BR>
 Copyright (c) 2020, Hewlett Packard Enterprise Development LP. All rights reserved.<BR>
 SPDX-License-Identifier: BSD-2-Clause-Patent
 
@@ -44,6 +44,7 @@ SPDX-License-Identifier: BSD-2-Clause-Patent
 
 #define CONFIG_HEADER_BN_H
 
+#if !defined(SIXTY_FOUR_BIT) && !defined (THIRTY_TWO_BIT)
 #if defined(MDE_CPU_X64) || defined(MDE_CPU_AARCH64) || defined(MDE_CPU_IA64) || defined(MDE_CPU_RISCV64)
 //
 // With GCC we would normally use SIXTY_FOUR_BIT_LONG, but MSVC needs
@@ -56,6 +57,7 @@ SPDX-License-Identifier: BSD-2-Clause-Patent
 #else
 #error Unknown target architecture
 #endif
+#endif
 
 //
 // Map all va_xxxx elements to VA_xxx defined in MdePkg/Include/Base.h