diff --git a/MdePkg/Library/BaseMemoryLibSse2/BaseMemoryLibSse2.inf b/MdePkg/Library/BaseMemoryLibSse2/BaseMemoryLibSse2.inf
index 55faea0d75..8ab21350b4 100644
--- a/MdePkg/Library/BaseMemoryLibSse2/BaseMemoryLibSse2.inf
+++ b/MdePkg/Library/BaseMemoryLibSse2/BaseMemoryLibSse2.inf
@@ -57,6 +57,7 @@
   Ia32/CompareMem.S
   Ia32/ZeroMem.nasm
   Ia32/ZeroMem.S
+  Ia32/SetMem64.nasm
   Ia32/SetMem64.S
   Ia32/SetMem32.S
   Ia32/SetMem16.S
@@ -74,6 +75,7 @@
   Ia32/CompareMem.asm
   Ia32/ZeroMem.nasm
   Ia32/ZeroMem.asm
+  Ia32/SetMem64.nasm
   Ia32/SetMem64.asm
   Ia32/SetMem32.asm
   Ia32/SetMem16.asm
diff --git a/MdePkg/Library/BaseMemoryLibSse2/Ia32/SetMem64.nasm b/MdePkg/Library/BaseMemoryLibSse2/Ia32/SetMem64.nasm
new file mode 100644
index 0000000000..727cea91fa
--- /dev/null
+++ b/MdePkg/Library/BaseMemoryLibSse2/Ia32/SetMem64.nasm
@@ -0,0 +1,60 @@
+;------------------------------------------------------------------------------
+;
+; Copyright (c) 2006, Intel Corporation. All rights reserved.<BR>
+; This program and the accompanying materials
+; are licensed and made available under the terms and conditions of the BSD License
+; which accompanies this distribution.  The full text of the license may be found at
+; http://opensource.org/licenses/bsd-license.php.
+;
+; THE PROGRAM IS DISTRIBUTED UNDER THE BSD LICENSE ON AN "AS IS" BASIS,
+; WITHOUT WARRANTIES OR REPRESENTATIONS OF ANY KIND, EITHER EXPRESS OR IMPLIED.
+;
+; Module Name:
+;
+;   SetMem64.nasm
+;
+; Abstract:
+;
+;   SetMem64 function
+;
+; Notes:
+;
+;------------------------------------------------------------------------------
+
+    SECTION .text
+
+;------------------------------------------------------------------------------
+;  VOID *
+;  EFIAPI
+;  InternalMemSetMem64 (
+;    IN VOID   *Buffer,
+;    IN UINTN  Count,
+;    IN UINT64 Value
+;    )
+;------------------------------------------------------------------------------
+global ASM_PFX(InternalMemSetMem64)
+ASM_PFX(InternalMemSetMem64):
+    mov     eax, [esp + 4]              ; eax <- Buffer
+    mov     ecx, [esp + 8]              ; ecx <- Count
+    test    al, 8
+    mov     edx, eax
+    movq    xmm0, qword [esp + 12]
+    jz      .0
+    movq    qword [edx], xmm0
+    add     edx, 8
+    dec     ecx
+.0:
+    shr     ecx, 1
+    jz      @SetQwords
+    movlhps xmm0, xmm0
+.1:
+    movntdq [edx], xmm0
+    lea     edx, [edx + 16]
+    loop    .1
+    mfence
+@SetQwords:
+    jnc     .2
+    movq    qword [edx], xmm0
+.2:
+    ret
+