diff --git a/OvmfPkg/IntelTdx/IntelTdxX64.dsc b/OvmfPkg/IntelTdx/IntelTdxX64.dsc
index 73a6c30096..80c331ea23 100644
--- a/OvmfPkg/IntelTdx/IntelTdxX64.dsc
+++ b/OvmfPkg/IntelTdx/IntelTdxX64.dsc
@@ -57,6 +57,11 @@
 !endif
 !endif
 
+  #
+  # Define the FILE_GUID of CpuDxe for unique-processor version.
+  #
+  DEFINE UP_CPU_DXE_GUID  = 6490f1c5-ebcc-4665-8892-0075b9bb49b7
+
 [BuildOptions]
   GCC:RELEASE_*_*_CC_FLAGS             = -DMDEPKG_NDEBUG
   INTEL:RELEASE_*_*_CC_FLAGS           = /D MDEPKG_NDEBUG
@@ -550,7 +555,30 @@
 
   MdeModulePkg/Universal/EbcDxe/EbcDxe.inf
   UefiCpuPkg/CpuIo2Dxe/CpuIo2Dxe.inf
-  UefiCpuPkg/CpuDxe/CpuDxe.inf
+
+  UefiCpuPkg/CpuDxe/CpuDxe.inf {
+    <LibraryClasses>
+      #
+      # Directly use DxeMpInitLib. It depends on DxeMpInitLibMpDepLib which
+      # checks the Protocol of gEfiMpInitLibMpDepProtocolGuid.
+      #
+      MpInitLib|UefiCpuPkg/Library/MpInitLib/DxeMpInitLib.inf
+      NULL|OvmfPkg/Library/MpInitLibDepLib/DxeMpInitLibMpDepLib.inf
+  }
+
+  UefiCpuPkg/CpuDxe/CpuDxe.inf {
+    <Defines>
+      FILE_GUID = $(UP_CPU_DXE_GUID)
+
+    <LibraryClasses>
+      #
+      # Directly use MpInitLibUp. It depends on DxeMpInitLibUpDepLib which
+      # checks the Protocol of gEfiMpInitLibUpDepProtocolGuid.
+      #
+      MpInitLib|UefiCpuPkg/Library/MpInitLibUp/MpInitLibUp.inf
+      NULL|OvmfPkg/Library/MpInitLibDepLib/DxeMpInitLibUpDepLib.inf
+  }
+
   OvmfPkg/LocalApicTimerDxe/LocalApicTimerDxe.inf
   OvmfPkg/IncompatiblePciDeviceSupportDxe/IncompatiblePciDeviceSupport.inf
   OvmfPkg/PciHotPlugInitDxe/PciHotPlugInit.inf
diff --git a/OvmfPkg/IntelTdx/IntelTdxX64.fdf b/OvmfPkg/IntelTdx/IntelTdxX64.fdf
index 9e290ea78f..1029916c34 100644
--- a/OvmfPkg/IntelTdx/IntelTdxX64.fdf
+++ b/OvmfPkg/IntelTdx/IntelTdxX64.fdf
@@ -185,7 +185,10 @@ INF  MdeModulePkg/Core/RuntimeDxe/RuntimeDxe.inf
 INF  MdeModulePkg/Universal/SecurityStubDxe/SecurityStubDxe.inf
 INF  MdeModulePkg/Universal/EbcDxe/EbcDxe.inf
 INF  UefiCpuPkg/CpuIo2Dxe/CpuIo2Dxe.inf
+
 INF  UefiCpuPkg/CpuDxe/CpuDxe.inf
+INF  FILE_GUID = $(UP_CPU_DXE_GUID) UefiCpuPkg/CpuDxe/CpuDxe.inf
+
 INF  OvmfPkg/LocalApicTimerDxe/LocalApicTimerDxe.inf
 INF  OvmfPkg/IncompatiblePciDeviceSupportDxe/IncompatiblePciDeviceSupport.inf
 INF  OvmfPkg/PciHotPlugInitDxe/PciHotPlugInit.inf
diff --git a/OvmfPkg/OvmfPkgX64.dsc b/OvmfPkg/OvmfPkgX64.dsc
index 45ffa2dbe3..71526bba31 100644
--- a/OvmfPkg/OvmfPkgX64.dsc
+++ b/OvmfPkg/OvmfPkgX64.dsc
@@ -72,6 +72,12 @@
 !endif
 !endif
 
+  #
+  # Define the FILE_GUID of CpuMpPei/CpuDxe for unique-processor version.
+  #
+  DEFINE UP_CPU_PEI_GUID  = 280251c4-1d09-4035-9062-839acb5f18c1
+  DEFINE UP_CPU_DXE_GUID  = 6490f1c5-ebcc-4665-8892-0075b9bb49b7
+
 [BuildOptions]
   GCC:RELEASE_*_*_CC_FLAGS             = -DMDEPKG_NDEBUG
   INTEL:RELEASE_*_*_CC_FLAGS           = /D MDEPKG_NDEBUG
@@ -728,7 +734,29 @@
   MdeModulePkg/Universal/Variable/Pei/VariablePei.inf
   OvmfPkg/SmmAccess/SmmAccessPei.inf
 !endif
-  UefiCpuPkg/CpuMpPei/CpuMpPei.inf
+
+  UefiCpuPkg/CpuMpPei/CpuMpPei.inf {
+    <LibraryClasses>
+      #
+      # Directly use PeiMpInitLib. It depends on PeiMpInitLibMpDepLib which
+      # checks the PPI of gEfiPeiMpInitLibMpDepPpiGuid.
+      #
+      MpInitLib|UefiCpuPkg/Library/MpInitLib/PeiMpInitLib.inf
+      NULL|OvmfPkg/Library/MpInitLibDepLib/PeiMpInitLibMpDepLib.inf
+  }
+
+  UefiCpuPkg/CpuMpPei/CpuMpPei.inf {
+    <Defines>
+      FILE_GUID = $(UP_CPU_PEI_GUID)
+
+    <LibraryClasses>
+      #
+      # Directly use MpInitLibUp. It depends on PeiMpInitLibUpDepLib which
+      # checks the PPI of gEfiPeiMpInitLibUpDepPpiGuid.
+      #
+      MpInitLib|UefiCpuPkg/Library/MpInitLibUp/MpInitLibUp.inf
+      NULL|OvmfPkg/Library/MpInitLibDepLib/PeiMpInitLibUpDepLib.inf
+  }
 
 !include OvmfPkg/OvmfTpmComponentsPei.dsc.inc
 
@@ -760,7 +788,30 @@
 
   MdeModulePkg/Universal/EbcDxe/EbcDxe.inf
   UefiCpuPkg/CpuIo2Dxe/CpuIo2Dxe.inf
-  UefiCpuPkg/CpuDxe/CpuDxe.inf
+
+  UefiCpuPkg/CpuDxe/CpuDxe.inf {
+    <LibraryClasses>
+      #
+      # Directly use DxeMpInitLib. It depends on DxeMpInitLibMpDepLib which
+      # checks the Protocol of gEfiMpInitLibMpDepProtocolGuid.
+      #
+      MpInitLib|UefiCpuPkg/Library/MpInitLib/DxeMpInitLib.inf
+      NULL|OvmfPkg/Library/MpInitLibDepLib/DxeMpInitLibMpDepLib.inf
+  }
+
+  UefiCpuPkg/CpuDxe/CpuDxe.inf {
+    <Defines>
+      FILE_GUID = $(UP_CPU_DXE_GUID)
+
+    <LibraryClasses>
+      #
+      # Directly use MpInitLibUp. It depends on DxeMpInitLibUpDepLib which
+      # checks the Protocol of gEfiMpInitLibUpDepProtocolGuid.
+      #
+      MpInitLib|UefiCpuPkg/Library/MpInitLibUp/MpInitLibUp.inf
+      NULL|OvmfPkg/Library/MpInitLibDepLib/DxeMpInitLibUpDepLib.inf
+  }
+
 !ifdef $(CSM_ENABLE)
   OvmfPkg/8259InterruptControllerDxe/8259.inf
   OvmfPkg/8254TimerDxe/8254Timer.inf
diff --git a/OvmfPkg/OvmfPkgX64.fdf b/OvmfPkg/OvmfPkgX64.fdf
index 6e72cdf345..aa9a83032d 100644
--- a/OvmfPkg/OvmfPkgX64.fdf
+++ b/OvmfPkg/OvmfPkgX64.fdf
@@ -185,6 +185,7 @@ INF  MdeModulePkg/Universal/Variable/Pei/VariablePei.inf
 INF  OvmfPkg/SmmAccess/SmmAccessPei.inf
 !endif
 INF  UefiCpuPkg/CpuMpPei/CpuMpPei.inf
+INF  FILE_GUID = $(UP_CPU_PEI_GUID) UefiCpuPkg/CpuMpPei/CpuMpPei.inf
 
 !include OvmfPkg/OvmfTpmPei.fdf.inc
 
@@ -239,7 +240,10 @@ INF  MdeModulePkg/Core/RuntimeDxe/RuntimeDxe.inf
 INF  MdeModulePkg/Universal/SecurityStubDxe/SecurityStubDxe.inf
 INF  MdeModulePkg/Universal/EbcDxe/EbcDxe.inf
 INF  UefiCpuPkg/CpuIo2Dxe/CpuIo2Dxe.inf
+
 INF  UefiCpuPkg/CpuDxe/CpuDxe.inf
+INF  FILE_GUID = $(UP_CPU_DXE_GUID) UefiCpuPkg/CpuDxe/CpuDxe.inf
+
 !ifdef $(CSM_ENABLE)
   INF  OvmfPkg/8259InterruptControllerDxe/8259.inf
   INF  OvmfPkg/8254TimerDxe/8254Timer.inf